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Journal: JCI Insight
Article Title: Adiponectin signaling regulates urinary bladder function by blunting smooth muscle purinergic contractility
doi: 10.1172/jci.insight.188780
Figure Lengend Snippet: ( A ) Representative traces of WT BSM contraction in response to EFS ( n = 4) before (blue) and after (red) exposure to AMPK inhibitor BAY-3827. ( B ) Representative traces of atropine-pretreated WT male BSM contraction in response to EFS ( n = 6) before (blue) and after (red) exposure to AMPK inhibitor BAY-3827. ( C and D ) Summarized data from experiments in the formats of A and B . ( E ) Representative traces of WT male BSM contraction in response to EFS ( n = 8) before (blue) and after (bed) exposure to AMPK activator A769662. ( F ) Representative traces of atropine-pretreated WT male BSM contraction in response to EFS ( n = 6) before (blue) and after (red) exposure to AMPK activator A769662. ( G – I ) Summarized data from experiments in the formats of E and F . Data are plotted in box (75% of the data) and whisker format (minimum to maximum), with centerline as median value. One-way ANOVA was used to examine the differences among groups of specific EFS frequency; data were then compared to control responses with a paired Student’s t test to assess the effect before and after drug intervention. * P < 0.05.
Article Snippet: AMPK inhibitor BAY-3827 (catalog HY-112083),
Techniques: Whisker Assay, Control